A five-year-old girl died on Saturday when she became trapped in her family's Woodberry home, in the Hunter region, after the fire broke out about 10am (AEST).
Her grandmother managed to escape with a seven-year-old child before crews worked for over an hour to extinguish the blaze.
Earlier in the day, fire crews were called to a burning home at Hamilton, in Newcastle's west, about 6.15am (AEST).
They dragged a 55-year-old unconscious man to safety and rushed him to John Hunter Hospital in a critical condition.
He was transferred to Royal North Shore Hospital and died the same day.
On Sunday about 5.30am (AEST), emergency crews arrived at another Woodbury home engulfed in flames.
The body of a 97-year-old man was found in the wreckage, but the man's son, aged in his 60s, and his teenage grandson were able to make it out of the house safely.
On Thursday, an 83-year-old man died in a house fire in Ashfield, in Sydney's inner-west.
Firefighters were called to the burning home about 3.30pm (AEST) and rescued the man who died at the scene.
NSW Fire Brigades Commissioner Greg Mullins said on Sunday that residents should review their fire safety procedures.
"I'm appealing to all NSW residents to make sure they have working smoke alarms, home escape plans, and to be extremely careful with heaters, fires and cooking," Com Mullins said in a statement.
"This is especially important during the winter months when we use heaters, open fires, clothes dryers, and electrical appliances, and tend to cook more hot meals,."
Residents are urged to visit www.homefiresafetyaudit.com.au and www.3minutes.com.au for fire safety tips.
